The experience of the Genetic Centre in Kuwait is worth attention, study, meditation and scientific analysis.

The story began since twenty years, definitely on the 1^st of February 1979. The journey of the big challenge went on quiet with balanced steps. Different genetic clinics in Al Sabah Hospital, Amiri Hospital, Al Jahra Hospital, Adan Hospital, Maternity Hospital and in Kuwait Cancer Centre were established to present the free genetic counselling to all Kuwaiti people and residents who need such service. Moreover, the centre can also serve the people of the Gulf Cooperation Council (GCC) states after making the required arrangements with the officials in the Ministry of Health.

Many defined aims were put forward with the officials in the Ministry of Health while thinking of establishing centre for the genetic illnesses in Kuwait:

The First Aim :

Diagnosis of some rare illnesses that need the opinion of the specialized geneticist and performing especial laboratory tests, which were not available in Kuwait.

The Second Aim :

Presenting the genetic counselling to the families with children who have different genetic abnormalities and to couples planning for marriage, especially those who have family history of genetic disorders.

The Third Aim :

Making studies which enable recognizing genetic problems, in this part of the world, to draw attention to the means of reducing newborn death rates and rates of disability in the community.

The Fourth Aim :

Training as much as possible numbers of doctors and technicians, locally, to provide suitable crews (which consist of doctors, technicians, nurses and social advisors) to work in the field of genetic counselling.

The Fifth Aim :

Making specialized medical services reachable for all the people in different Kuwaiti regions and sharing our knowledge and experiences with those who are in charge of the medical services in other countries in general and the Arab and GCC countries in particular.

It is possible to divide the story of establishing the genetic centre into the following five stages :

The First Stage (1977-1980):

The centre was opened offecially by his Excellency Dr. Abdul Rahman Al Awadi on 27.11.1980 in the Maternity Hospital. Before this, the genetic services start as a weekly genetic clinic (every Monday) in the 9^th ward, Children’s Department in Al Sabah Hospital. That clinic received the cases sent to it by the colleagues in the hospitals and private clinics. Blood samples used to be sent to USA (Los Angeles), to UK (London) and to the Biology Department in the Faculty of Science for chromosomal analysis. During this stage, the required medical records were made available to study different genetic disease, which include :

1- Infertility cases (for men and women)

2- Cases of repeated and spontaneous abortion, especially in the first trimester of pregnancy.

3- Congenital malformations involving different body systems.

4- Cases of possible chromosomal disorders (like Down syndrome, Turner Syndrome or Klinafelter Syndrome etc.).

5- Mental retardation (especially this runs in families).

6- Hearing impairment.

7- Ophthalmological disorders.

8- Cases of short stature (especially those repeated in the same family or brothers).

9- Haematological Diseases (like Haemophilia, sickle cell anaemia, Thalassaemia, G6PD deficiencies …etc.)

10- Cases of pre-marital counselling (especially those who have genetic problems).

The Second Stage (1981-1982):

In this stage Down syndrome clinics were established. The centre has 12 clinics per month which were divided as follows :-

1. A clinic in the children’s department in Al Sabah Hospital (on Sundays and Tuesdays)

2. A clinic in the Genetic Centre in Maternity Hospital (on Wednesday)

Blood samples, from suspected patients, were collected and sent for analysis either in Kuwait or abroad.

The Third Stage (1983-1984):

After making sure that the scientific frame and organization of the Genetic Centre is able to present the specialized services for people in different regions of Kuwait, establishing Genetic Clinics, in these regions became necessary. The first genetic clinic was established in Al Jahra in the beginning of 1983 which, initially operated once per week and later doubled its working time to twice per week (on Sundays and Wednesdays). After that, genetic clinic was established in Farwaniya and Al Adan Hospitals. This experience became unique and pioneer in the medical service in the field of genetic counselling which is not available in most of the countries of the world.

The Fourth Stage (1985-1989):

After the opening of the genetic clinic at Al Amiri Hospital in February 1985 the Genetic Centre was running 48 clinics per month for. Work was as follow:

Saturday Al Amiri

Sunday Al Sabah & Al Jahra Hospitals – Salmiya Specialized Centre

Monday Al Adan and Farwania Centres

Tuesday Al Sabah Hospital, Al Sulaibiya Polyclinic

Wednesday Down syndrome clinic in Maternity, Al Jahra and Al- Adan Hospitals.

The Fifth Stage (1991-2003):

This stage developed quickly as the Genetic Centre was rebuilt after the Iraqi invasion in 1990 as the centre witnessed a great damage. The Genetic Centre was developed to contain a Department of Molecular Laboratory to provide diagnostic services and carrier detection for a greater number of genetic diseases and then establishmed the Laboratory of Fluorescence in Situe Hybridization (FISH) to pay more attention to the field of cancer genetic.

In addition to the previous clinics, which were serving all different areas in Kuwait, a clinic for familial cancer patients was opened in Kuwait Cancer Centre.

Kuwait Medical Genetic Centre is now serving larger number of patients with a well experienced staff and with a very well equipped laboratories including the cytogenetic, molecular and FISH labs to help in the diagnosis of genetic disorders, genetic counselling and to perform genetic studies in this area of the world.

Future Prospectives:

A new building for the Kuwait Medical Genetic Centre is now in progress. This centre will be equipped with the up to date instruments. This will extende the clinical and investigational facilities of the centre to cover more areas of genetic services that are not available now

The services in Kuwait Medical Genetic Centre are provided through:

1. Clincs

2. Cytogenetic Laboratory

3. Molecular Genetic Laboratory

4. Fluorescence In Situ Hybridization (FISH) Laboratory

Topics:

Dysmorphology

Common population Genetics

Cytogenetics

Molecular Cytogenetics

Molecular Genetics

Biochemical Genetics

Blood Disorders

Endocrinal Disorders

Cancer Genetics

Dead Line: For Abstracts 31 December 2005

For Registration 30 November 2005

E-mail: kmgc2006@yahoo.com

1979

(1) Kabarity A, Al-Awadi SA, Farag TI. Incomplete form of Leopard syndrome. J Kwt Med Assoc., 13:213-220.

1980

(2) Al-Awadi SA, Farag TI, Naguib K. Clinicopathological and cytogenetic study of a true hermaphrodite presumed to be an XX/XO mosaic. (Abstract in J Med Genet., pg220.

(3) Kabarity A, Al-Awadi SA, Farag TI, Malallah G. Heritable “Uncomplicated” profound childhood deafness in an Arabic family with consanguinity rate. J Kwt Med Assoc., 14:101-110.

1981

(4) Kabarity A, Al-Awadi SA, Farag TI, Malallah G. Autosomal recessive “uncomplicated” profound childhood deafness in an Arabic family with high consanguinity. Hum Genet (Abstract:57:444-446).

(5) Al-Awadi SA, Farag TI, Naguib K, Cuschieri A, Issa M. Familial jejunal atresis with ‘apple peel’ variant. J Roy Soc Med., 74:499-501.

(6) Al-Awadi SA, Kabarity A, Farag TI, Naguib K. Clinicopathological and cytogenetic study of a true hermaphrodite with presumptive XX/XO mosaicism. J Kwt Med Assoc., 15:39-47.

1982

(7) Al-Awadi SA, Farag TI, Teebi AS, Devarajan LV. Brachmann de Lange syndrome in an Arab girl. J Kwt Med Assoc., 16:55-60.

(8) Al-Awadi SA, Farag TI, Naguib K, Cuschieri A, Masterson JG. Wolf-Hirschhorn syndrome in an Arabic girl. J Irish Coll Physics & Surg., 11, 3:115-116.

1983

(9) Zahran MH, Al-Awadi SA, Gothi R, Naguib K. Iliac Index, radiological evaluation and clinicl usefulness. Bull Alex Fac Med., Vol. XIX (4):843-847.

(10)Al-Awadi SA, Farag TI, Cuschieri A, Naguib K, Teebi AS. Autosomal recessive inheritance of intestinal atresia. J Roy Soc Med., 76:434-435.

(11)Al-Awadi SA, Cuschieri A, Farag TI, Naguib K, Teebi AS, Issa M, El-Sayed M. Mixed gonadal dysgenesis and sex chromosome mosaicism with multiple cell lines including structural aberrations of the Y chromosome. Clin Genet., 23:172-176.

(12)Al-Awadi SA, Cuschieri A, Farag TI, Naguib K, Teebi AS, Al-Othman, SA, Bahig AH. Ullrich-Turner syndrome in monozygotic twins. Am J Med Genet., 15:537-542.

(13)Al-Awadi SA, Farag TI, Naguib K, Teebi AS. Three sibs with Aarskog-Scott syndrome (McK 20450) Clin Genet., 23 (3):223 (Abstract).

(14)Al-Awadi SA, Farag TI, Naguib K, Teebi AS, Cushchieri A. Six hemizygous male sibs with X-linked recessive hydrocephalus. Clin Genet., 23, 3:224 (Abstract).

(15)Al-Awadi SA, Farag TI, Naguib, Teebi AS, Cuschieri A, Al-Othman SA, Sundareshan TS. Interstitial deletion of the long arm of chromosome 2:del(2)(q31q33). J Med Genet., 20(6):464-465.

(16)Al-Awadi SA, Farag TI, Nguib K, Teebi AS, Cuschieri A, Yousef F, Hassan S. Bilateral total gonadectomy in Ullrich-Turner syndrome. J Kwt Med Assoc., 17:241-244.

1984

(17)Al-Awadi SA, Farag TI, Naguib K, El-Khalifa MY, Cuschieri A, Hosny G, Zahran M, Al-Ansari AG. Spondyloepiphyseal dysplasia tarda with progressive arthropathy. J Med Genet., 21 (3):193-196.

(18)Al-Awadi SA, Farag TI, Teebi AS, Naguib K, El-Khalifa MY. Anencephaly: Disappearing in Kuwait. Lancet.,ii, 701-702.

(19)Al-Awadi SA, Farag TI, Naguib K, Teebi AS, El-Khalifa MY, Yassin S. X-linked hydrocephalus (Bickers-Adams-Edwards-syndrome). J Kwt Med Assoc., 18:187-190.

(20)Al-Awadi SA, Farag TI, Naguib KK, Teebi AS, El-Khalifa MY, Al-Othman SA, Sundareshan TS, Mustfa F, Abulhasan S, Ramadan AA, Redha AA. A five year experience with gonosomal abnormalities in Kuwait. J Kwt Med Assoc., 18:225-232 (Abstract) Am J Hum Genet 36 (Suppl.) 4, 40S.

1985

(21) Al-Awadi SA, Teebi AS, Farag TI, Naguib K, El-Khalifa MY. Profound limb deficiency, thoracic dystrophy, unusual facies and normal intelligence: A new syndrome. J Med Genet., 22 (1):36-38.

(22)Al-Awadi SA, Farag TI, Tebi AS, Naguib K, El-Khalifa MY, Kelani Y, Al-Ansari A. Familial hypergonadotrophic, hypogonadism with partial dysplasia of skin appendage: A new autosomal recessive syndrome. Saud Med J., 6(4):335-360.

(23)Al-Awadi SA, Mousa MA, Naguib K, Farag TI, Teebi AS, El-Khalifa MY, El-Dossary L. Consanguinity among the Kuwaiti population. Clin Genet., 27:483-486.

(24)Al-Awadi SA, Farag TI, El-Khalifa MY, Al-Ansari AG. Fibrodysplasia ossificans progressiva. J Ropy Soc Med., 78:881-882.

(25)Al-Awadi, Farag TI, Teebi AS, Naguib K, El-Khalifa MY, Kelani Y, Al-Ansari AG, Schimke RN. Primary hypogonadism and partial alopecia in three sibs with Mullerian hypoplasia in the affected females. Am J Med Genet., 22:619-622.

(26)Al-Awadi SA, Teebi AS, Sundareshan TS. Complex chromosomal rearrangements involving chromosomes 11, 13, 14 and 18 resulting in monosomy for 13q32 qter. Ann Genet., 28:181-184.

(27)Al-Awadi SA, Teebi AS, Farag TI, Naguib KK, El-Khalifa MY, Al-Othman SA, Sundareshan TS A five year experience with autosomal abnormalities in Kuwait. J Kwt Med Assoc., 19:269-275.

1986

(28)Al-Awadi SA, Naguib KK, Teebi AS, Sundareshan TS. De novo partial monosomy 21 with unusual karyotype. Jpn J Hum Genet., 31:45-48.

(29)Al-Awadi SA, Farag TI, Usha R, El-Khalifa MY, Sundareshan TS, Al-Othman SA. Brief clinical report: Interstitial deletion of the long arm of chromosome 1 del(1)(q32q42). Am J Med Genet., 23:931-933.

(30)Al-Awadi SA, Naguib KK, Teebi AS, Devarajan LV, El-Khalifa MY. Lethal multiple pterygium syndrome: Report of two sporadic cases from Kuwait. J Kwt Med Assoc., 20:135-140.

(31)Al-Awadi SA, Naguib KK, Farag TI, Teebi AS, Cuschieri A, Al-Othman SA, Sundareshan TS. Complex translocation involving chromosome Y, 1 and 3 resulting in deletion of segment 3q23 q25. J Med Genet., 23(1):91-92.

(32)Al-Awadi SA, Teebi AS, Krishnamurthy DS, Othman G, Sundareshan TS. Klinefelter’;s syndrome mosaic 46,XX/46,XY/47,XXY/48,XXXY/48,XXYY: A case report. Ann Genet., 29(2):119-121.

(33)Al-Awadi SA, Farag TI, Teebi AS, Naguib KK, Aref MA, El-Badramany MH, El-Khorafi N, Al-Kassaby TA. Tetrasomy X (48,XXXX syndrome). J Kwt Med Assoc., 20:57-60.

(34)Al-Awadi SA, Farag TI, Naguib KK, Teebi AS, El-Khalifa MY, Marafie MJ, Al-Othman SA, Sundareshan TS, Krishnamurthy DS. Cytogenetic profile of Down’s syndrome in the Arabs: A study of 603 cases in Kuwait during 1979-1986. Am J Hum Genet., 39(3), A102(300) [Abstract].

(35)Al-Awadi SA, Naguib KK, Mousa MA, Farag TI, Teebi AS, El-Khalifa MY. The effect of consanguineous marriages on reproductive wastage. Clin Genet., 29:384-388.

(36)Farag TI, Teebi AS, Al-Awadi SA. Non syndromal anencephaly: Possible autosomal recessive variant. Am J Med Genet., 24:373-378.

(37)TeebiAS, Al-Awadi SA, Farag TI, Naguib KK. Hypogonadotropic hypogonadism, mental retardation, obesity and minor skeletal abnormalities: Another new autosomal recessive syndrome from the Middle East. Am J Med Genet., 24:373-378.

(38)Teebi AS, Al-Awadi SA. Spondyloepiphyseal dysplasia tarda with progressive arthropathy: A rare disorder frequently diagnosed among Arabs. J Med Genet., 23:189-191.

(39)Naguib KK, Al-Awadi SA, Farag TI, Teebi, AS, El-Khalifa MY, Deverajan LV, Shaath R. Amniotic band syndrome and fetal deformations. J Kwt Med Assoc., 20:89-97.

(40)Portoin-Shuhaiber S, Al-Awadi SA, Farag TI, Sundareshan TS, Jindal HR, Al-Rashied AA. Clinical findings in an Arab boy with ring (14) (mos46,XY,r(14)/45,XY,-14). Ann Genet., 29(2):122-124.

(41)Teebi AS, Al-Awadi SA, Opitz JM, Spranger J. Severe short limb dwarfism resembling Grebe chondrodysplasia. Hum Genet., 74:386-390.

(42)Bessiso MS, Teebi AS, Al-Awadi SA, Al-Rashied AA. Schwartz-Jampel syndrome. A case study and electromyographic findings. J Kwt Med Assoc., 20(3 & 4): 195-199.

(43)Naguib KK, Al-Awadi SA, Mousa MA, Farag TI, Teebi AS, El-Khalifa MY, Deverajan LV, Shaath R. Major congenital malformations among livebirths in Kuwait. Am J Hum Genet (Abstract) 39(3) A73:213.

(44)Farag TI, Al-Awadi SA, Teebi AS, Naguib KK, Sundareshan TS, El-Khalifa MY, Marafie MJ, Al-OthmaN sa, Krishnamurthy DS. Rare chromosomal syndromes in Kuwait: A seven years experience. Am J Hum Genet (Abstract) 39(3) A113:332.

1987

(45)Teebi AS, Al-Awadi SA, White AG. Autosomal recessive nonsyndromal microcephaly with normal intelligence. Am J Med Genet., 26:355-359.

(46)Teebi AS, Al-Awadi SA, Farag TI, Naguib KK, El-Khalifa MY. Phenylketonuria in Kuwait and Arab countries. Eur J Pediatr., 146:59-60.

(47)Naguib KK, Teebi AS, Al-Awadi SA, Mousa MA, Ali NR. Multiple pterygium syndrome in five Arab sibs. Ann Genet., 30(2):122-125.

(48)Farag TI, Sundareshan TS, Al-Awadi SA, Al-Othman SA, Shimbeye AG, El-Khalifa MY, Krishnamurthy DS. Ring chromosome 14 in an Arab boy with unusual cytogenetic findings. J Kwt Med Assoc., 21(2):105-109.

(49)Naguib KK, Teebi AS, Al-Awadi SA, Marafie MJ. Brachmann de Lange syndrome in sibs. J Med Genet., 24:627-629.

(50)Farag TI, Al-Awadi SA, Hunt MC, Styanath S, Zahran M, Usha R, Uma R. A family with spondylo-epi- metaphyseal dwarfism. A ‘New’ dysplasia or kniest disease of autosomal recessive inheritance? J Med Genet., 24:597-601.

(51)Farag TI, Krishnamurthy DS, Al-Awadi SA, Sundareshan TS, Al-Othman SA, Mady S, Redha MA. Robertsonian translocation t dic (14p;22p) with regular trisomy 21: A possible interchromosomal effect? Ann Genet., 30(3):189-192.

(52)Farag TI, Al-Awadi SA, Tippett P, El-Sayed M, Sundareshan TS, Al-Othman SA, El-Badramany MH. Unilateral true hermaphrodite with 46,XX/46,XY dispermic chimerism. J Med Genet., 24:784-786.

(53)Mahfouz EH, Issa MA, Farag TI, Naguib KK, Teebi AS, El-Khalifa MY, Al-Awadi SA. Down syndrome and intestinal malformations in Kuwait. J Kwt Med Assoc., 21(3):197-200.

(54)Farag TI, Krishnamurthy DS, Al-Awadi SA, Al-Othman SA, Al-Hijji SY, El-Badramany MH. Klinefelter’s syndrome mosaic XX/XY/XXY/XXXY/XXXXY/XXXYY associated with hyperdiploidy: A case report. Am J Hum Genet., 41(3) Sept.(Suppl.)A118(348).

(55)Naguib KK, Al-Awadi SA, Marafie MJ, Al-Hijji SY. Trisomy 18 clustering in Kuwait. Clin Genet., 32(6):379-382.

(56)Farag TI, Teebi AS, Naguib KK, El-Khlifa MY, Marafie MJ, Sundareshan TS, Al-Othman SA, Al-Awadi SA. Cytogenetic profile of Klinefelter’s syndrome in Kuwait. A study of 80 cases. J Kwt Med Assoc., 21(4):299-303.

(57)Al-Awadi SA, Naguib KK, Farag TI, Teebi AS. Hypoplastic tibiae with postaxial polysyndactyly: A new dominant syndrome? J Med Genet., 24:369-372.

(58)Al-Awadi SA, Farag TI, Naguib KK, Teebi AS, El-Khalifa MY, Marafie, Issa MA, Mahfouz ESH. Intestinal malformations and Down syndrome in Arabs. J Roy Soc Med., 80-61-62.

(59)Al-Awadi SA, Farag TI, Teebi AS, Naguib KK, Al-Othman SA, Sundareshan TS, Krishnamurthy DS. Downs syndrome in Kuwait: Cytogenetic profile in 635 cases and comparative study with world-wide surveys. J Kwt Med Assoc., 21(3):191-196.

(60)Al-Awadi SA, Teebi AS, Farag TI, Naguib KK. Inherited metabolic disease in Kuwait. The need for a nation wide screening programme. In: Advances in neonatal screening (ed.) Therrell, Elsevier, Science Publisher B.V.Amsterdam, 479-480.

(61)Al-Awadi SA, Farag TI, Teebi AS, El-Khalifa MY, El-Fadala S, Parikh SD. Otologic abnormalities in 53 Arab Downs syndrome children. J Kwt Med Assoc., 21(4):342-343.

1988

(62)Krishnamurthy DS, Sundareshan TS, Farag TI, Al-Awadi SA, Al-Othman SA. Frequency of acrocentric chromosome association in familial Robertsonian translocation, t dic (14p;22p)+21. Am J Hum Genet 43(3) Sept. (Suppl.) A111:0442.

(63)Al-Awadi SA, Farag TI, Satyanath S, Sundareshan TS. Metacarpophalangeal pattern profile analysis in partial 9p monosomy. Am J Med Genet 29:217-219.

(64)Al-Awadi SA, Naguib KK, Al-Othman SA, Sundareshan TS. Trisomy 4q:46,XY,-11,+der(11),t(4;11)(q27;q25) pat in a child with multiple congenital anomalies. Ind J Paediatr., 55:308-311.

(65)Farag TI, Al-Awadi SA. Strategies in liaison and regional community genetic services in developing communities: a lesson from the Amrish. Clin Genet., 34(6):395.

(66)Manandhar MC, Farag TI, Hafez SA, Al-Awadi SA, Palkovic M, Hunt MCJ. Familial hypercholesterolemia: Is there a need for early detection and treatment. J Kwt Med Assoc., 22 (1):60-63.

(67)Teebi AS, Al-Awadi SA, Farag TI, Naguib KK. New Mendelizing gene disorders in Kuwait. 24^th Pan Arabs Medical Congress [Abstract] 222; p.233.

(22)Teebi AS, Al-Awadi SA, Marafie MJ, Bushnaq RA, Satyanath S. Osteroporosis-pseudoglioma syndrome with congenital heart disease: a new assocition. J Med Genet 25:32-36.

(23)Teebi AS, Naguib KK, Al-Awadi SA, Al-Saleh QA. New autosomal recessive facio-digital-genital syndrome. J Med Genet 25:400-406.

(24)Farag TI, Al-Awadi SA, Al-Othman SA, Sundareshan TS, Krishnamurthy DS, Usha R, Mady SA, Uma R. Down syndrome and trisomy 18 in the Bedouins. Am J Med Genet 29:943-944.

(25)Naguib KK, Al-Awadi SA, Teebi AS, Farag TI, Mowafi R, Marafie MJ, Ramadan AA. Holoprosencephaly in Kuwait: A study of thirteen cases and literature review. J Kwt Med Assoc., 22(1):41-4.

(26)Naguib KK, Sundareshan TS, Bahar AM, Al-Awadi SA, Jeryan LA, Hamdan MR. Fertility with deletion Xq25: report of three cases; possible exceptions for critical region hypothesis. Fert & Steril; 49(5):917-919.

(27)Al-Awadi SA, Farag TI, Teebi AS, Naguib KK, Sundareshan TS, Ramadan AA, Krishnamurthy DS. Robertsonian translocation and their clinical implications: A study of 35 cases. J Kwt Med Assoc., 22(3):263-266.

(28)Teebi AS, Al-Awadi SA, Al-Awqati, Farag TI, Naguib KK. Neonatal screening for phenylketonuria and congenital hypothyroidism in Kuwait. A preliminary report. In: Proceedings of the 6^th neonatal screening symposium, May 22-25, Portland Eds. Skeels, Buist and Tuerk p.150151.

1989

(29)Naguib KK, Al-Awadi SA, Moussa MA, Farag TI, Teebi AS. Effect of parental age, birth order and consanguinity on nondisjunction in the population of Kuwait. J Kwt Med Assoc., 23(1): 37-43.

(30)Teebi AS, Krishnamurthy DS, Sundareshan TS, Al-Awadi SA, Jeryan LA, Baidas G, Dahouk WS. Structural abnormalities of the Y chromosome associated with hypospadius, infertility and short stature. Ann Saud Med 9(4):414-422.

(31)Al-Awadi SA, Sundareshan TS, Teebi AS, Hashash N, Abu Al-Assad FM, Aboobacker KC. Distal 10q trisomy: A clinically recognizable syndrome. MPP 1:112-114.

(32)El-Kishawi AR, Malek AH, Al-Awadi SA, Teebi AS. Hallermann-Streif syndrome. J Kwt Med Assoc., 23(1):80-81.

(33)Mohammed FM, Farag TI, Gunawardana SS, Al- Digashim DD, Al-Awadi SA, Al-Othman SA, Sundareshan TS. Direct duplication of chromosome 1, dir dup(1)(p21.1 → p32) in a Bedouin boy with multiple congenital anomalies. Am J Med Genet., 32:353-355.

(34)Teebi AS, Sundareshan TS, Hammouri MY, Al-Awadi SA, Al-Saleh QA. A new autosomal recessive disorder resembling weaver syndrome. Am J Med Genet., 33:479-482.

(35)Teebi AS, Al-Saleh QA, Hassoon MM, Farag TI, Al-Awadi AS. Macrosomia, microphthalmia + Cleft palate and early infant death: a new autosomal recessive syndrome. Clin Genet., 36:174-177.

(36)El-Khalifa MY, Farag TI, Naguib KK, Teebi AS, Mrafie MJ, Bastaki L, Al-Awadi SA, El-Badramany MH. Early diagnosis of hermaphroditism in a mixed Arab population. Am J Hum Genet [Abstract] 45 (Suppl.) A44[0167].

(37)Mohammed FM, Farag TI, Al-Awadi SA, Al-Othman SA, Al-Jeryan LA. Triploidy syndrome. A report of aliveborn Bedouin baby with multiple congenital anomalies, ambiguous external genitalia and nonmosaic 69,XXY karyotype. Am J Hum Genet [abstract] 45 [Suppl.] A56; 212.

(38)Farag TI, Al-Awadi SA, Yassin S, El-Kassaby TA, Jaefary S, Usha R, Uma R, Mady SA, Fakhr M, Mannae M, Senarthe S, Khan TS. Anencephaly: a vanishing: a vanishing problem in Bedouin? J Med Genet 26(8):538-540.

(39)Farag TI, Teebi AS, Al-Awadi Sam, El-Ramly MA. Monozygotic twins concordant for Bardet-Biedl syndrome and Benign Acanthosis Nigricans. Med Principles & Pract., 1:60-62.

(40)Ahmed OA, Al-Rimawi HS, Al-Rashied AA, Farag TI, Sundareshan TS, Al-Awadi SA, Al-Othman SA. Fanconi’s anaemia with acute lymphoblastic leukemia in a Bedouin girl. Am J Hum Genet., 45[Suppl.] A14;(0047).

(41)Farag TI, Kelani YAZ, Teebi AS, Naguib KK, Sundareshan TS, Al-Awadi SA, El-Khalifa MY, Marafie MJ, Bastaki L, Al-Othman SA. Clustering of major chromosomal abnormalities among unselected sterile men in Kuwait. Med Principles & Pract., 1:232-235.

(42)Farag TI, Rao VK, El-Khalifa MY, Sundareshan TS, Marafie MJ, Voncina D, Simsek M, Mady SA, Al-Othman SA, Al-Awadi SA. Autosomal recessive Duchenne-like muscular dystrophy in Arabs Report of a Kuwaiti family and literture review. Med Principles & Pract., 1:96-101.

(43)Naguib KK, Al-Awadi, Mousa MA, Farag TI, Teebi AS, El-Alfi A, Marafie MJ, Al-Aboud H. Syndromal and nonsyndromal cleft lip +cleft palate in Kuwait. Ann Saud Med 9(4):388-392.

(44)Naguib KK, Teebi AS, Farag TI, Al-Awadi SA, El-Khalifa, Mahfouz E. Familial uterine hernia syndrome. Report of a family with 4 affected males. Am J Med Genet., 33:180-181.

(45)Krishnamurthy DS, Naguib KK, Al-Awadi, Sundareshan TS, Al-Othman SA, Hayat AA. Clinical & Cytogenetic, studies in familial polycystic ovarian disease. J Obstet Gynae 10:133.

(46)El-Badramany MH, Farag TI, Al-Awadi, SA, IM Hammad, Abdelkhader A, Krishnamurthy DS. Familial manic-depressive illness with deleted short arm of chromosome 21: coincidental or causal? Brit J Psych 155:856-857.

(47)Qasrawi BM, Frag TI, Bessiso M, Marafie MJ, Al-Awadi SA, Mohammed FM, Al-Othman SA, El-Khalifa MY. Wolf-Hirschhorn syndrome (4p-) in an institutionalised mentally retarded boy. The 8^th Medical Conference of the Kuwait Med Assoc [Abstract] p;86.

(48)Hafez SA, Manandhar DS, Farag TI, Palkovic M, Al-Awadi SA, Al-Nagdi K. Familial hyperlipoproteinemias (FHLP) in the Jahra area. The 8^th Medical Conference of the Kuwait Med Assoc [Abstract] p;58-59.

1990

(49)Krishnamurthy DS, Sundareshan TS, Farag TI, Al-Awadi SA, Al-Othman SA. Segration of acrocentric chromosome association in familial dicentric Robertsonian translocation t(14p;22p) aneuploidy (trisomy 21) and heteromorphism. Ind J Expermtl Biol., 2, June, p511-515.

(50)Sundareshan TS, Naguib KK, Al-Awadi SA, Redha MA, Hamoud MS. Apparently nonmosaic trisomy 22: Clinical report & review. Am J Med Genet 36(1):7-10.

(51)Naguib KK, Al-Awadi SA. Letter to the Editor: Hypoplastic tibiae with postaxial polysyndactyly in two sibs: Further confirmation of a new syndrome. Am J Med Genet., 35:29-30.

(52)Al-Awadi SA, Farag TI, Teebi AS, Naguib KK, Sundareshan TS, Krishnamurthy DS. Down syndrome in Kuwait. Am J Med Genet., 7:87-88.

(53)Abulhasan SJ, Teebi AS, Zaki M, Hammad I, Al-Awadi SA, Krishnamurthy DS. Mosaicism 45,X/46,X,t dic(Xp;Xp;) in a girl with short stature. Ann Genet., 33(4):234-238.

(54)Farag TI, Al-Awadi SA, Usha R, Uma R, Mady SA, Al-Nagdy KA, Al-Badramany MH. Phenotypic variability in Meckel-Gruber syndrome. Clin Genet., 38:176-179.

(55)Krishnamurthy DS, Teebi AS, Sundareshan TS, Al-Awadi SA. Familial fragile secondary constriction on chromosome 2(q11) in a child with unusual features and psychomotor retardation. Ind J Paediatr., 57:257-260.

(56)Mahfouz EH, Issa MA, Farag TI, Naguib KK, Al-Awadi, Schimke RN. Persistent Mullerian Duct Syndrome: Report of two boys with associated crossed testicular ectopia. J Pediat Surg., Vol.25;(6) June : 692-693.

1991

(57)Al-Awadi SA, Farag TI, Teebi AS, Naguib KK, El-Khalifa MY, Marafie MJ, Bastaki L, Al-Othman SA, Sundareshan TS, Krishnamurthy DS, Mohammed FM, Abulhasan SJ, Redha AA, Ramadan AA. Cytogenetic profile of Down syndrome in Kuwait: A decade of experience. J Egypt Pub Health Assoc Int Conf Hum Genet., Vol. LXVI-Suppl., 259-269.

1992

(58)Usha R, Uma R, Farag TI, Girish Y, Al-Ghanem MMA, Al-Nagdi K, Al-Awadi SA, El-Badramany MH. Late diagnosis of phenylketonuria in a Bedouin mother. Am J Med Genet 44:713-715.

(59)Al-Awadi SA, Al-Othman SA, Marafie MJ, Bastaki L, Mohammed EM, Redha AA, Abulhasan SJ, Redha MA, Al-Jeryan L, Al-Hashash N, Al-Khorafi H, Haji IAQ, Al-Suleiman I, Al-Balool RI, Al-Qaud B. Re-establishment of genetic services in Kuwait. Am J Hum Genet 51(4): Suppl. A416(1640).

(60)Farag TI, Al-Awadi SA, El-Badramany MH. Prevalence of Wilson’s disease among Bedouins. Am J Hum Genet 51(4): Suppl. A338(1330).

(61)Krishnamurthy DS, Al-Awadi SA, Farag TI. Pericentric inversions and recombinant aneusomy and other associated chromosomal aberrations. Random or nonrandom? Am J Hum Genet 51(4): Suppl. A291(1146).

(62)Marafie MJ, Redha MA, Al-Awadi SA, Farag TI. Tetrasomy X in Kuwait. Am J Hum Genet; 51(4); Suppl. A306(1207).

(63)Al-Awadi SA, Al-Othman SA, Mohammed FM, Abulhasan SJ, Redha AA, Farag TI, Naguib KK, Teebi AS, El-Khalifa MY, Marafie MJ, Bastaki L, Kahlon PS, Cuschieri A, Sundareshan TS, Krishnamurthy DS. Kuwait Cytogenetics Registry. [Abstract] 11^th Int Chromo C onf, Edinburgh, Scotland, Aug., A2; p.745.,

(64)Farag TI, Al-Awadi SA, Krishnamurthy DS. Nonclassical karyotype in Down syndrome. [Abstract]. 11^th Int Chromo Conf, Edinburgh, Scotland, Aug; A10; p.74.

(65)Al-Awadi SA, Farag TI, Marafie MJ, Bastaki L, El-Khalifa MY, Yadav G, Qasrawi BM, Al-Othman SA, Mohammed FM, Abulhasan SJ, Redha AA, Al-Khaorafi H, Suleiman IA, Krishnamurthy DS. Clinicogenetic study of 430 institutionalised mentally retarded in Kuwait. International Association for the Scientific study of Mental deficiency. Australia, August. [POSTER SESSION].

(66)Yadav G, Farag TI, Al-Awadi SA, Sam T, Mrafie MJ, Bastaki L, El-Khalifa MY, Kasrawi B, Wahba RA. Letter to the Editor: Aminocidopathies among institutionalised mentally retarded in Kuwait. Clin Genet 42(4), Oct. p.212.

(67)Bastaki L, Al-Awadi SA, Naguib KK. Incidence of Genodermatosis, among the neonates in Kuwait Maternity Hospital. 2^nd Scientific meeting of Dermatology, Venereology and Andrology, Kuwait April 14-16, p.64.

(68)Abulhasan SJ, Al-Awadi SA, Mohammed FM, Al-Saleh WA, El-Saee Lotfy, Farag TI, Teebi AS, Krishnamurthy DS. Sister chromatid exchanges (SCEs) and familial palmoplantar keratoderma. 2^nd Scientific meeting of Dermatology, Venereology and Andrology. April 14-16.

(69)Naguib KK, Marafie MJ, Bastaki L, Al-Awadi SA, Attia MS, Al-Tawary AA. Holoprosencephaly clustering in Kuwait. Bull High Inst Pub Health. Vol.XXII; No.1:117-124.

(70)Naguib KK, Mousa MA, Al-Awadi SA, Mohammed FM, Attia MS. Down syndrome in sibs: A study of recessive hypothesis controlling nondisjunction. Bull High Inst Pub Health. Vo.XXII; No.1:125-133.

1993

(71)Farag TI, Al-Awadi SA, El-Khalifa MY, Teebi AS, Naguib KK, El-Badramany MH. True and pseudohermaphroditism: A decade of experience in Kuwait. Med Principles Pract 3:156-159.

(72)Farag TI, Al-Awadi SA, Marafie MJ, Bastaki L, Krishnamurthy DS, Al-Othman SA, Mohammed FM, Redha AA, Abulhasan SJ, Redha MA, Al-Jeryan L, Al-Hashash N, Al-Khorafi H, Haji IAQ, Al-Suliman I, Al-Nagdi K, Al-Ghanem M, Usha R, Mady SA, Uma R. Letter to the Editor: Clustering of cri-du-chat syndrome among Bedouins. Am J Med Genet 46:347-348.

(73)Farag TI, Al-Awadi SA, Marafie MJ, Bastaki L, Al-Othman SA, Mohammed FM, Al-Suliman IS, Krishnamurthy DS. The newly recognised limb/pelvis-hypoplasia/aplasia syndrome: report of a bedouin patient and review. J Med Genet 30:62-64.

(74)Mohammed FM, Krishnamurthy DS, Farag TI, Al-Awadi SA, Al-Othman SA, Hammad I. Familial pericentric inversion of chromosome 13, 46,XX,inv(13)(p13;q11): A new variant. Ann Genet 36(3):181-185.

(75)El-Shenawy MM, Al-Qattan SI, El-Mostehy MR, Al-Awadi SA. Oral manifestations in Arab Down’s syndrome children: a collaborative study. J Kwt Med Asoc., 25:103-106.

(76)Farag TI, Al-Awadi SA, Krishnamurthy DS et al. Disease profile of 400 institutionalised mentally retarded in Kuwait. Clin Genet; 44:329-333.

(77)Farag TI, Al-Awadi SA, El-Badramany MH, Usha R, El-Ghanem M. Letter to the editor: Second family with “Apple Peel” syndrome affecting four siblings: Autosomal recessive inheritance confirmed. Am J Mede Genet., 47:119-121.

1994

(78)Al-Awadi SA, Abulhasan SJ, Mohammed FM, Farag TI, Krishnamurthy DS, Al-Saleh QA, El-Saee L, Tayeh M, Sakr MF. Familial palmoplantar keratoderma, malignancy and sister chromatid exchanges. The Guldf J Dermatol., 1:40-43.

(79)Mohammed FM, Krishnamurthy DS, Farag TI, Jain SJ, Hammad IM, Al-Rashied AA, Al-Awadi SA. Chromosomal abnormalities in Fanconi anaemia. J Kwt Med Assoc., 26(1):43-47.

(80)Al-Awadi SA, Farag TI, Krishnamurthy DS, Al-Azemi MK, Qurton M. A letter to the Editor: Mixed gonadal dysgenesis with structural anomalies of the Y chromosome. Ann Saud Med; Vo. 14(3):267-268.

(81)Redha AA, Krishnamurthy DS, Kandil H, Farag TI, Usha R, Al-Awadi SA, Jeryan L, Al-Nagdy K, El-Ghanem M.. Partial trisomy of short arm of chromosome 8 [46,XY,inv dup(8)(p21 → pter)] in a Bedouin child with multiple congenital anomalies and mental retardation. Ind J Pediatr 61:301-306.

(82)Al-Awadi SA, Krishnamurthy DS, Farag TI, Mohammed FM, Abulhasan SJ, Redha AA, Redha MA, Al-Jeryan LA. Cytogenetic findings in the referred population in Kuwait. Am J Hum Genet [Abstract] 55(3):Suppl.A314; 1836.

(83)Palkovic M, Rajaram U, Al-Ghanem MM, Khawan EM, Kandil HH, Al-Awadi SA, Farag TI. Hyperlipoproteinemia among Bedouins: Cord blood study. Am J Hum Genet [Abstract] 55(3):Suppl;A283; 1662.

(84)Krishnamurthy DS, Al-Awadi SA, Bastaki L, Mohammed FM, Farag TI. Y Chromosome polymorphism: Possible largest Y chromosome in man? Am J Hum Genet [Abstract] 55(3):Suppl;A318; 1864.

(85)Sabry MA, Al-Othman SA, Krishnamurthy DS, Gouda SA, Marafie MJ, Bastaki L, Al-Awadi SA, Farag TI. Clustering of major chromosomal abnormalities among azoospermic males in Kuwait: A study of 280 patients. Med Principles & Pract. 95(4):68-74.

(86)Sabry MA, Al-Awadi SA, El-Alfi A, Gouda SA, Kazi NA, Farag TI. Poland syndrome associated dextrocardia in Kuwait. Med Principles & Pract., 4:121-126.

(87)Al-Awadi Sadika A. Cytogenetic profile of Down syndrome in Kuwait. The 9^th Scientific Congress of the KMA. [Abstract] Oct.17-20, p.102-103.

(88)Farag TI, Bastaki L, Marafie MJ, Al-Awadi SA. Autosomal Recessive Congenital Diaphragmatic Defects in the Arabs. Am J Med Genet., 50:300-301.

(89)Farag TI, Samilchuk E, Abulhasan SJ, Al-Awadi SA, Kandil H, Mady SA, El-Ghanem M. Cystic fibrosis in Kuwait and neighbouring populations. JKMA 26; No.2: 176-179.

1995

(90)Sabry MA, Al-Saleh Q, Al-Saw’an R, Al-Awadi SA, Farag TI. Right upper limb bud triplication and polythelia, left-sided hemihypertrophy, and congenital hip dislocation, facial dysmorphism, congenital heart disease and scoliosis: Disorganisation like spectrum or patterning gene defect? J Med Genet; 32:555-556.

(91)Sabry MA, Mubashir MA, Haseeb N, Al-Awadi SA, Farah S, Qasrawi B, Al-Dabbous RM, Al-Busairi W, Farag TI. A possible new nonchromosomal syndromic situs inversus total is in a institutionalised patient. Am J Hum Genet.

(92)Al-Harbi MK Al-Awadi SA, Naguib KK. Proteus syndrome in an Arab child. JKMA 27(4):313-315.

(93)Samilchuk E, Farag TI, Al-Awadi SA. Molecular mechanism of nonmendelian inheritance in genetic disease. Med Principles & Pract; 4:1-7.

(94)Qasrawi BM, El-Gamal SA, Farag TI, Al-Awadi SA, Al-Gendi II, Sabry MA. A possible new craniofacio fronto digital dysplasia?. Am J Hum Genet.

(95)Qasrawi BM, Mobashir MA, Al-Gamal SA, Muhammad AR, Al-Busairi WA, Badawi RM, Al-Awadi SA, Sabry MA, Farag TI. Late diagnosis of PKU in an institutionalised Bedouin child: Rehabilitation approach.

(96)Al-Harby MK, Naguib KK, Al-Awadi SA, Hamdy NF. Gordon syndrome in sibs: A new variant? JKMA 28(1):53-56.

(97)Gouda SA, Bastaki L, Al-Awadi SA, Al-Mazeidi Z, Al-Ghanem M, Sabry MA, Farag TI. Silver-Russell syndrome in Bedouin sibs: Autosomal recessive inheritance confirmed. Am J Hum Genet, Suppl.59(4); Oct. A/94; No. 509. [Abstract in the 10^th Scientific Congress of the KMA 1996; pg.245-246].

(98)Krishnamurthy DS, Al-Awadi SA, Farag TI, Gouda SA, AbdelRasool MA. Ring chromosome 11 [46,XX,r(1)(p15q25)] in a Bedouin child with dysmorphism and mental retardation: A case report and brief review. Am J Hum Genet; Suppl. 59(4); Oct.A/360; No. 2099.

(99)Krishnamurthy DS, Farag TI, Al-Awadi SA, Wahby M, Noor A. Familial pericenric inversion of chromosome 1, inv(1) (p11:q21) associated with inguinal hernia in Bedouin sibs. The JKMA, Vol.27;(2):143-145.

(100) Al-Torki NA, Al-Awadi SA, Cinfro-Heberie L, Sabry MA. Geroderma osteodysplastica ina Bedouin sibship: Further delineation of the syndrome [Abstract in Am J Hum Genet; Suppl. 59(4); Oct. A/347; No. 2021]. Paper published in Clin Dysmorph (1997) 6:51-55.

(101) Naguib KK, Tayel KY, Abdelhamid AA, Nofal L. Familial Left handedness. Bull HIPH, 1995.

(102) Bastaki L, Naguib KK, Al-Awadi SA, Marafie M, Dabbous N. Congenital malformation in Kuwait: An over view study. Alex J Ped, 1995,1, 99.

1996

(103) Redha M, Krishnamurthy DS, Al-Suliman IS, Al-Awadi SA, Sabry MA, El-Bahey SA, Farag TI. De novo direct duplication of 7p (p11.3 pter) in an Arab child with MCA/MR syndrome: Trisomy 7p, a delineated syndrome? Am J Hum Genet; 39(1):5-9.

(104) Sabry MA, Ohenbergerova D, Al-Sawan R, Al-Saleh Q, Farah S, Al-Awadi SA, Farag TI. Femoral hypoplasia unusual facies syndrome with bifid hallux absent tibia, and macrophallus: A report of Bedouin baby. J Med Genet; 33:165-167.

(105) Mubashir MA, Farag TI, Sabry MA, Al-Awadi SA, Kandil H, Usha R, Mady SA, Al-Ghanem M, Qasrawi B, Al-Busairi W. Phenylketonuria in four Bedouin sibs. Med Principles Pract; 5:167-171.

(106) Al-Awadi SA, Naguib KK. Genetics in Public Health. The 10^th Scientific Congress of the KMA. [Abstrct] pg. 225.

(107) Naguib KK, Al-Awadi SA, Bastaki L, Gouda SAR, Al-Harbi MK. An overview of neural tube defects in Kuwait. The 10^th Scientific Congress of the KMA. [Abstract] pg. 225.

(108) Naguib KK, Al-Awadi SA, Bastaki L, Gouda SA, El-Naggar RL. Consanguinity among patients with neural tube defects. The 10^th Scientific Congress of the KMA [Abstract] pg. 226.

(109) Al-Torki NA, Al-Awadi SA, Al-Kandari NH, Al-Tawari A. Craniofacial dys-synostosis with cryptorchidism, skin pigmentaion and normal stature. The 10^th Scientific Congress of the KMA [Abstract] pg. 226-227.

(110) Naguib KK, Al-Etrebi NN, Al-Awadi SA, El-Harbi MK. Complete testicular feminization syndrome with 47,XYY karyotype: A double hit phenomenon. The 10^th Scientific Congress of the KMA. [Abstract] pg227.

(111) El-Naggar RL, Mady SA, Al-Awadi SA, Al-Ghanem M, Abulhasan SJ, Sabry MA, Farag TI, Bastaki L, Naguib KK, Gouda SA, Usha R, Uma R. Profile of chromosomal abnormalities in Al-Jahra region of Kuwait. The 10^th Scientific Congress of the KMA [Abstract] pg 224.

(112) Samilchuk Elena, D’Souza Brendan, Al-Awadi Sadika A. Molecular diagnostic and carrier identification for metabolic diseases in Kuwait. The 10^th Scientific Congress of the KMA. [Abstract] pg.245.

(113) Fouda Hamdy, Al-Tawri Asma, Gouda Sayed AR, Al-Awadi Sadika, Naguib Kamal K. Spotlight n partial epilepsy of childhood in Kuwait. The 10^th Scientific Congress of the KMA [Abstract] p.246.

(114) Sabry MA, Al-Saleh Q, Farrah S, Obenbergerova D, Simeonov S, Al-Awadi SA, Farag TI. Another Arab patient with overlap of Varadi-Papp-Opitz Trigonocephaly syndromes? [Abstract] in the 10^th Scientific Congress of the KMA, p.244.

(115) Al-Alfi Abla, El-Harbi MK, Mowafi Raouf S, Al-Eneizi Eman, Al-Awadi SA, Naguib KK. Twin reversed arterial perfusion (TRAP) sequence. JKMA 28(3):303-306.

(116) Samilchuk Elena, D’Souza Brendan, Bastaki Laila, Al-Awadi Sadika A. Deletion analysis of the SMN and NAIP genes in Kuwaiti patients with spinal muscular atrophy. Hum Genet; 98:524-527.

(117) Samilchuk Elena, D’Souza Brendan, Al-Awadi Sadika A. A Kuwaiti patient with osteopetrosis, renal tubular acidosis and cerebral calcification is homozygous for a splice junction mutation in the carbonic anhydrase gene. Med Principles & Pract., 5:234-237.

(118) Sabry MA, Al-Awadi SA, Redha M, Krishnamurthy DS, Sabry HM, Farag TI. Syndromic dextrocardia associated with a de novo partial deletion of the short arm of chromosome 12 in an Arab girl. Am J Hum Genet., 59(4):A361; 2107.

(119) Farrah S, Rudwan M, Al-Saleh Q, Al-Haj B, Qasrawi B, Hassan, Al-Awadi SA, Sabry MA, Farag TI. Sjögren-Larsson syndrome: Clinical and Neuroradiological Findings in an Institutionalised Bedouin Patient. Med Principles & Pract., 5:114-117.

(120) Al-Awadi SA, Shaheen WA, Bastaki L, Gouda SAR, Naguib KKuib. Familial laryngomalacia: A case report of 9 affected relatives. Alex J Pediatr., vol.1: 23-25.

(121) Samilchuk Elena, D’Souza Brendan, Al-Awadi Sadika A. Molecular diagnostics and carrier identification for metabolic diseases in Kuwait. Proceeding of the 10^th Scientific Congress of the Kuwait Medical Association. Paper presentation, pg.164-165.

(122) D’Souza Brenda, Samilchuk Elena, Al-Awadi Sadika A. Frequency of the G6PD – Meditterranean mutation in Kuwait. Pg. 156-157.

1997

(123) Hamoud MS, Naguib KK, Al-Saouri HA, Al-Awadi SA, Fakhry RZ. Pancreatic agenesis appearing in Kuwait. Med Principles Pract., 6:26-29.

(124) AlNaggar RL, AlAwadi SA, Sabry MA, Tayel S and AlKandari F: Blepharophimosis, ptosis, epicanthus inversus syndrome in a Palestinian boy. Proceeding of international symposium (Tunis 1997) POSTER.

(125) Sabry MA, Al-Saleh Q, Farrah S, Obenbergerova D, Simeonov S, Al-Awadi SA, Farag TI. Another Arab patient with overlap of Varadi-Papp-Opitz Trigonocephaly syndromes? Am J Med genet; 68:54-57.

(126) Al-Torki NA, Al-Awadi SA, Cinfro-Herberie L, Sabry MA. Gerodermia osteodysplastica ina Bedouin sibship: Further delineation of the syndrome. Clin Dysmorph; 6:51-55.

(127) Samilchuk Elena, D’Souza Brendan, Voevodin Alexander, Chucalin Alexander, Al-Awadi Sadika A. Taqi polymorphism in the 3’ flanking region of the PI gene among Kuwaiti Arabs & Russians. Disease Markers; 3:87-92.

(128) Sabry MA, Isamil EAR, El-Naggar RL, Al-Torki NA, Farrah S, Al-Awadi SA, Obenbergerova D, Bastaki L. Unusual traits associated with Robinow syndrome. J Med Genet; 34:736-740.

(129) Al-Awadi SA, Krishnamurthy DS, Farag TI. Cytogenetic profile of Down Syndrome in Kuwait. [Abstracts. Int Conf on chromosome 21 and Med Research on Down syndrome]. Cytogenet & Cell Genet; March 14-15, 1997; Barcelona, Spain; 77:7; Suppl –1.

(130) Abulhasan SJ, Krishnamurthy DS, Rasool MA, Naguib KK, Al-Awadi SA. De novo duplication and cynamic mosaicism of chromosome 22 (q11 q12) and structural rearrangement [translocation 5, 7, 14] in the father: A case report. Am J Hum Genet; (Suppl.) 61(4), Oct. 1997 [Abstract]. No. 2173.

(131) Sabry MA, Al-Shubaili A, Maghrabi MA, Farrah S, Abulhasn SJ, AbdelRasool MA. Al-Awadi SA. Identification of chromosome 15q11-12 haplo-insufficiency in the autistic disorder. Am J Hum Genet (Abstract) 61(4), Oct.No.2193.

(132) Al-Torki NA, Abulhasan SJ, Sabry MA, AbdelRasool MA, Jameh IA, Al-Awadi SA. Saggital/Coronal craniosynostosis associated with balanced reciprocal translocation [t(2;8)(2p16;8p22)] in an Arab girl. Am J Hum Genet 61(4); Oct. (Abstract) No.2174.

(133) Murthy SK, Krishnamurthy DS, Bastaki L, Al-Nasser KE, Varghese L, Al-Awadi SA. Molecular cytogenetic analysis of duplication of X chromosome [de novo 47,XY,+dup(X)(q13;q28)] in a male with hypogonadism and psychomotor retardation. Am J Hum Genet; (Suppl.) 61(4):Oct, 1997 [Abstract] No. 769.

(134) Krishnamurthy DS, Farag TI, Al-Awadi SA. Pericentric inversion of chromosome 1 and 9 [46,XY,inv(1)(p12;q13) inv(9)(p1;q12),16qh+] in a male with reproductive failure. Am J Hum Genet. Suppl.61(4): A373; No.2182.[Abstract]

1998

(135) Krishnamurthy DS, Tayel SM, Abulhaszn SJ, Bastaki L, Al-Awadi SA. De novo dup 13q(q21 → qter) in a child with cryptophtholmosis and craniofacial anomalies. A case report. Am J Hum Genet. Supplement, Vol.63(4) Oct. 1998;[Abstract No. 795; p.A141].

(136) Abulhasan SJ, Tyel SM, AbdelRasool MA, Al-Tahoo J, Al-Awadi SA. Mosaic Turner Syndrome: Cytogenetics versus FISH. [Abstract No. 703, p A126. Am J Hum Genet; Suppl. 63(4) Oct. 1998.

(137) Sabry MA, Shaltout AA, Zaki M, Al-Mezeidi Z, Abulhasan SJ, Al-Torki NA, Quishvi A, Al-Awadi SA, Farag TI. Kenny-Caffey syndrome: An Arab variant. Abstract No. 659; p.A118.

(138) Redha MA, Naguib KK, Al-Awadi SA, Krishnamurthy DS. Down syndrome due to translocation t(13q;21q): A case report. Health Sciences Poster Day – April 20, 1998; Faculty of Medicine, Kuwait University.

(139) Krishnamurthy DS, Soni AL, Tayel SM, Al-Torki NA, Al-Rasool MA, Al-Sawan RMZ, Al-Awadi SA. Trisomy 13 due to De Novo Homologous Robertsonian Translocation t(13:13) in a newborn with cyclopia and multiple congenital anomalies: A case report. Health Sciences Poster day – April 20, 1998, Faculty of Medicine, Kuwait University.

(140) Naguib KK, Al-Awadi SA, Bastaki L, Mousa MA, Azab AS, El-Harbi MS. Consanguinity among patients with Neural Tube Defects. The KMJ, Vol.30,(4):292-296.

(141) D’Souza Brendan, Samilchuk Elena, Al-Awadi Sadika A. Molecular Analysis of the G6PD – Mediterranean mutation in Kuwait. Med Principles & Pract., 7:209-214.

(142) Samilchuk EI, AL-Suleiman IS, Al-Awadi SA. Population frequency of the main haemochromatosis mutation (GyS282 Tyr) in Arabs & Russian. Health Sciences Poster day – April 20, 1998, pg.31; Faculty of Medicine, Kuwait University.

(143) Al-Naggar RL, Tayel SM, Al-Awadi SA. Double aneuploidy, 48,XXY,+18 in a Bedouin boy: A case report. Health Science Poster day, April 20, pg.30; Faculty of Medicine, Kuwait University.

(144) Sabry MA, Zaki M, Abulhasan SJ, Ramadan DG, AbdelRasool MA, Al-Awadi SA, Al-Saleh Q. Kenny-Caffey syndrome is part of the CATCH 22 haploinsufficiency cluster. J Med Genet; Jan; 35:(1):31-36.

(145) Farah S, Farag TI, Sabry MA, Simeonov STm, Al-Khattam S, Abulhasan SJ, Qasrawi B, Al-Busairi Q, Al-Awadi SA. Cutis Verticis Gyrata-Mental Deficiency syndrome: Report of a case with unsual neuroradiological findings.

1999

(146) El-Naggar RL, Tayel SM, Al-Awadi SA, Abulhasan SJ, Mady SA, Al-Ghanem MM, Abu Henedi MM, Bastaki L. Heterochrony of the extremities due to chromosomal abnormalities. [Abstract] Cytogenet & Cell Genet; p565.

(147) Al-Awadi SA, Abu-Henedi MM, El-Naggar RL, Bastaki L, Abulhasan SJ. Angelman’s syndrome: A brief clinical and FISH report on Kuwaiti patients. [Abstract] Cytogenet & Cell Genet; p.564.

(148) Tayel SM, Abou Karsh NA, Abulhasan SJ, Krishnamurthy DS, Eweidah MH, Aduma FA, Al-Awadi SA. A case of de novo balanced reciprocal translocation (Xp;1p) and a phenotype suggestive of deletion 1p36.3. [Abstract] Cytogenet & Cell Genet; p707.

(149) Tayel SM, El-Naggar RL, Ali FE, Al-Awadi SA. Two-step fragile X screening program in mentally retarded males. [Abstract] Cytogenet & Cell Genet Conference Vienna, Austria 1999; p708. [Paper published in KMJ, 31(3):257-262.

(150) Al-Awadi SA, Naguib KK, Bastaki L, Gouda SA, Mohammed FM, Abulhasan SJ. Al-Ateeqi QA, Krishnamurthy DS. Downs syndrome in Kuwait: Recurrent familial trisomy 21 in sibs. Med Principles & Pract; 8:156-163.

(151) Krishnamurthy DS, Surana SK, Al-Awadi SA. Hemiphypertrophy of limbs: A report of two cases. Health Sciences Poster day April, 25, 1999 – Faculty of Medicine, Kuwait University- Pg. 28.

(152) Samilchuk E, Al-Awadi SA. Genetic polymorphism of drug metabolizing enzymes: analysis of CYP2C19 variants in Kuwait. Health Sciences Poster Day, April 25, Faculty of Medicine, Kuwait University – Pg. 29.

(153) Samilchuk Elena, Al-Suleiman Ibrahim, Naqi Gadeer, Al-Awadi SA. Mutation and linkage analysis in genetic counseling for phenylketonuria in Kuwait. Med Principles Pract., 8:217-221.

(154) Naguib KK, Al-Awadi SA, Bastaki L, Mousa MA, Abulhasan SJ, Tayel SM, Krishnamurthy DS. Clustering of trisomy 18 in Kuwait: Genetic predisposition or environmental? Ann Saudi Med, 19(3):197-200.

(155) El-Naggar RL, Mady Sam Tayel SM, Farag TI, Al-Awdi SA, Al-Ghanem MM, Abulhasan SJ, Sabry MA, Bastaki L. Profile of chromosomal abnormalities in the Al-Jahra Region of Kuwait. Med Principles Pract, 8:167-172.

(156) Al-Awadi SA, El-Naggar RL, Tayel SM, Uma R. Double aneuploidy 48,XXY+18 in a Bedouin boy. Med Principles & Pract, 8:241-244.

(157) AlNaggar Rezk L, AlAwadi Sadika A, Obenbergerova D: Maternal diabetic embryopathy: Profound limb malformations in Kuwaiti Bedouin boy. 6^th UAE Paediatric Conference; February 1999 (Abstract).

(158) Abulhasan SJ, Tayel SM, Al-Awadi SA. Mosaic Turner Syndrome: Cytogenetics versus FISH. Am J Hum Genet 63:199-206.

(159) Abulhasan SJ, Bastaki L, Mohammed FM, Naguib KK, Gouda SAR, Al-Tahoo J, Al-Awadi SA. XX Male: A report of two unrelated cases & review of literature. Alex J Paedtr. Vol.13 (2):327-331.

(160) Samilchuk Elena, D’Souza brendan, Al-Awadi Sadika A. Population study of common glucose –6–phosphate dehydrogenase mutations in Kuwait. Hum Hered; 49:41-44.

(161) Tayel SM, El-Naggar RL, Krishnmurthy DS, Naguib KK, Al-Awadi SA. Familial pericentric inversion of chromosome 1 (p36.3 q23) and Bardet-Biedl syndrome. Letter to the Editor. J Med Genet; 36:418-419.

(162) Sabry MA, Farag TI, Shaltout AA, Zaki M, Al-Mazeidi Z, Abulhasan SJ, Al-Torki N, Quishawi A, Al-Awadi SA. Kenny-Caffey Syndrome: An Arab Variant? Clin Genet; 55: 44-49.

(163) Laila A. Bastaki, Sadika A. Al-Awadi, Allie Moosa, Rabah M. Shawky, Kamal K. Naguib. Clinico-Genetic study of dystrophinopathies: A comparative study between Kuwait and Egypt. Alex.J.Paeds, Vo.13,#2, July; 371-377.

(164) Laila A.Bastaki, M.Z.Haider, Rabah M.Shawky, Kamal K.Naguib. Genotype-Phenotype corelation among patients with dystrophinopathies. Alex J Paeds, vol.13,32,July; 365-370.

(165) SA Al-Awadi, MM Abu Heneidi, L Bastaki, SJ Abulhasan, RL Al Naggar. 2^nd international Conference on population and molecular genetics update. Poster, 22: p427.

(166) Sadika A. AlAwadi, Rezk Al Naggar, Laila A Bastaki, Maha M Abu Henedi, Obenbergerova D. Congenital hemihypertrophy, craniofacial, neurocutaneous and skeletal anomalies: Expanded proteus syndrome with a fatal course. 6^th UAG Paediatric Conference, February 1999 (Abstract).

2000

(167) Samilchuk, Al-Suleiman I, Usanga E, Al-Awadi S. UDP Glucuronosytransterase (UGT1A1) Gene promoter polymorphism among Kuwaitis with glucose-6-phosphophate dehydrogenase (G6PD) deficiency. Health Sciences Poster Day, April 24, 2000 Faculty of Medicine, Kuwait University; pg. 43.

(168) KrishnaMurthy DS, Al-Torki NA, Redha MA, Haji Iman AQ, Al-Awadi. Familial balanced robertsonian translocation t(15q;22q) associated with ganglioneuroma: Causal or Coincidental? Health Sciences Poster Day, April 24, 2000- Faculty of Medicine, Kuwait Univesity, pg. 39.

(169) KrishnaMurthy DS, Naguib KK, Soni AL, Bastaki L, Al-Awadi SA. Health Sciences Poster Day – April 24, 2000 – Faculty of Medicine, Kuwait University, pg. 38.

(170) Al-Naggar RL, Al-Awadi SA, Mady SA, Saleh SI, Raj Usha, Farag TI. Minor Morphogenetic variants: Seven-years study of neonates in Al-Jahra region of Kuwait. The Egypt J Med Hum Genet, Vol.1,(1), 173-180.

(171) Al-Awadi SA, Abu-Henedi MM, Bastaki L,. Abulhasan SJ, Al-Naggar RL. The Angelman Syndrome: Brief Clinical & FISH report on Kuwaiti patients. The Egypt J Med Hum Genet, Vol.1(1), 73-82.

(172) Al-Awadi SA, Al-Naggar RL, Bastaki L, Obenpergerova D, Abu-Henedi MM. Congenital Hemihypertrophy, craniofacial, neurocutaneous and skeletal anomalies: Expanded proteus syndrome with a fatal course. The Egypt J Med Hum Genet, Vol.1(1), 189-195.

(173) Redha AA, Gouda SA, Al-Awadi SA. Apparently balanced translocation t(10q;18q) in a child with delayed development: A case report. Health Sciences Poster Day, April 24, 2000 – Faculty of Medicine, Kuwait University, pg. 42.

(174) Krishna Murthy DS, Al-Torki NA, Abdulla SM, Al-Awadi SA. 48,XXYY syndrome: Clinical entity or klinefelter syndrome variant – A case report and brief review. Health sciences Poster Day – April 24, 2000 Faculty of Medicine, Kuwait University, pg.41.

(175) Krishna Murthy, Al-Torki NA, Bandar AA, Meshal, Al-Awadi SA. X Chromosome aneuploidy (47,XXX) associated with repeated spontaneous abortions: A case report.

(176) Al-Naggar Rezk L, Al-Awadi Sadika A, Obenbergerova D. Maternal diabetic embryopathy: Profound limb malformations in a Kuwaiti Bedouin boy. The KMJ, December 2000, 422-423.

(177) Laila Bastaki, Sadika A. Al-Awadi, Sawsan J Abul-Hasan, Effat A Abdul-Khalek, Ayman S.Azab, Sayed A.Gouda, Kamal K.Naguib. CATCH 22 in Kuwait: A study of 20 families. Alexandria Journal of Pediatric, Vo.14, No.1, pg. 101-106.

(178) L.A.Bastaki, S.A.Al-Awadi, A..Abul-Hasan, F.M.Mohammed, S.A.Gouda, K.K.Naguib. Familial Prader-Willi syndrome with unusual findings. The American Journal of Human Genetics, Supplement 1 Vol.67, No.4, October 2000, POSTERS 129.

2001

(179) Krishna Murthy DS, Dabbus R, Redha MA, Al-Rasool MA, Al-Awadi SA. Cri du chat syndrome due to maternal balanced translocation, 46,XX,t(5:16)(p15.2;q23): A case report and review. Health Sciences Poster Day – April 23, 2001 – Faculty of Medicine, Kuwait University.

(180) Murthy SK, Krishna Murthy DS, Al-Awadi SA. Fluorescence In Situ Hybridization (FISH), cytogenetic and DNA analysis of balanced complex chromosomal rearrangement involving chromosomes 13, 19 and 20: A case report. Health Sciences Poster Day – April 23, 2001 – Faculty of Medicine, Kuwait University.

(181) Samilchuk E, Al-Suliman I, Al-Awadi SA. Mutation analysis of phenylketonuria in Kuwait. Health Sciences Poster Day – April 23, 2001 – Faculty of Medicine, Kuwait University.

(182) Maha M. Abu-Heneidi, Sadika A.Al-Awadi, Laila Bastaki, Rezk L.Al-Naggar. Varadi-Papp syndrome (OFD-VI) in a Kuwaiti boy. The Egyptian Journal of Medical Human Genetics; Vol.2, No.2, Nov.2001.

(183) Najat M.Al-Awadi, Sadika A.Al-Awadi, Laila Bastaki, Rezk L.Al-Naggar. Lipids Profile, Haematologic and Biochemical Aspects: A study on Kuwaiti Down’s syndrome adolescents. The Egyptian Journal of Medical Human Genetics; Vol.2, No.2, Nov.2001.

(184) Maha M Heneidi, S A Al-Awadi, L Bastaki, A Al-Wadan, DS Krishnamurthy, RL Al-Naggar. Robert’s – Sc phocomelia syndrome in two infants with different ethnicity in Kuwait. Brief clinical report. [Abstract] Am J Hum Genet, Vol. 69, 686.

(185) SA Al-Awadi, MM Abu Heneidi, RL AlNaggar, L Bastaki, SJ AbulHasan. Angelman’s syndrome: A brief clinical and FISH report on Kuwaiti patients. 2^nd European cytogenetic. Conference, July 3-6, 1999, Vienna, Austria.

(186) RL Al Naggar, SA Al Awadi, SA Madi, MM Abu Heneidi, TI Farag, L Bastaki. Limb reduction defects in Al-Jahra Region of Kuwait (1983-1990). Am J Hum Genet (Abst.) 69 (4): 668, 2001.

2002

(187) Al-Awadi.A.Sadika, Al-Naggar R.L, Al-Awadi, N.M, Abu-Henedi MM, Bastaki L.A. Thyroid dysfunction, in children and adolescents with Downs syndrome in Kuwait. Am J Hum Genet, vol. 71(4)Suppl.- ABSTRACT #580.

(188) L.A.Bastaki, S.A.Al-Awadi, F.A.Hegazi, N.A.Turki, M.A.Mustafa, K.A.Naguib. PCR technique and significance in Fragile X syndrome. Am J Hum Genet, Vol.71(4)Suppl. – ABSTRACT#2072.

(189) DS Krishnamurthy, NA Turki, L Bastaki, RI Al-Ballol, SA Al-Awadi. Paternal balanced translocation, t(1p:19q)(p32;q13.4)associated with recurrent fetal loss – A case report. Am J Hum Genet, vo.71(40 suppl. – ABSTRACT#735.

(190) RL AlNaggar, SA AlAwdi, MM Abu-Heneidi, SA Gouda, H Fathi, L Bastaki. Osteopathia Striata with cranial sclerosis: A brief clinicl report on a Beoduin girl. Am J Hum Genet, vol.71(4) Suppl.- ABSTRACT#605.

(191) Samir Saleh, Rezk Al Naggar, Nadia Al Torki, Sadika A.Al-Awadi: Menkes Disease in a Kuwaiti Boy: A brief clinical Report. The Egyptian Journal Medical Human Genetics, 3(1):95-100.

2003

(192) Krishnamurthy DS, Ali MAA, AlNaggar RL, Al-Awadi SA: Ring chromosome 15: Clinical Heterogeneity and ring chromosome instability: A case report and review. Health Science Poster Day April, 2003.

(1) Kamal k Naguib, Laila A. Bastaki, Sadika A. Al Awadi, Ayman S. Azab: Panhypopitutrism, Craniofacial Dysmorphia, Hypogonadism and Mental Retardation: A New Syndrome.

(2) Kamal.K.Naguib., Laila A. Bastaki, Sadika A.Al-Awadi: Corpus callosum agenesis, Ambiguous external genitalia, Tetramicromelia, Polysyndactyly, coloboma of Iris: A new syndrome.

(3) Laila A. Bastaki, Sadika A.Al-Awadi, Kamal K. Naguib: Primary amenorrhea, Infantile uterus, Alopecia, Diabetes Mellitus, Intracranial calcification, in two sibs: A new syndrome.

(4) Hasan A. ElSori, Kamal K. Naguib, Magda S Hammoud: Gluteric aciduria Type I in a Kuwaiti infant.

(5) Sadika A.AlAwadi, Laila A. Bastaki, M.A.Mousa, Kamal K Naguib: Down syndrome in Kuwait: A comprehensive study of 1650 down syndrome patients.

(6) AlFahdli S, ElShafey A, Bastaki L, Al-Awadi S. CTG repeat length polymorphism at myotonic dystrophy locus in normal Kuwaiti population.